dosing guide · as printed in every lid
Tirzepatide 40
once weekly · 133 µg per click · 300 clicks per pen
Tirzepatide 40
once weekly · 133 µg per click · 300 clicks per pen
phase 01 Placeholder, pen at starting dose 
weeks 1–4 the on-ramp
2.5 mg · 19 clicks
once weekly · the studied starting dose
Tirzepatide's titration is the best-mapped in the incretin class. The opening dose is deliberately sub-therapeutic, it exists to build tolerance, not to move the curve. Little change in month one is the design, not a shortfall.
✦same weekday, morning or evening, pick one and keep it
✦mild GI markers in week one are common in the literature
✦fresh needle each time, pen refrigerated between doses
weeks 4–8 the working range
5 mg · 38 clicks
once weekly · where the phase-3 results begin
From week five the reference schedule enters the band where clinical results were recorded. Many research protocols hold here for months, the card only steps up again if the trend stalls for three-plus weeks.
✦hold the lowest dose that keeps the trend moving
✦protein reference ~1.6 g/kg to protect lean mass
✦rotate the injection site each week
phase 02 Placeholder, dial at step-up dose
phase 03 Placeholder, full reference dose 
weeks 8+ the ceiling, if needed
7.5 mg · 56 clicks
once weekly · only after 8+ settled weeks
The upper step of this pen. The published programme ran doses higher still, but most of the effect in the data arrives well below the maximum. Durability beats intensity across a twelve-month horizon.
✦escalate only if progress genuinely plateaus
✦a missed week: within four days or skip, never double
✦reorder early so cold shipping never interrupts the schedule
✦ This guide reproduces the printed dosing card and published research titration, it is a reference for laboratory research, not medical advice. See the research-use notice before use.
